IV Ketamine

Intravenous ketamine infusions have been effective in decreasing symptoms related to chronic pain syndromes, especially those that have a neuropathic component.

What is Ketamine?

Ketamine is a safe analgesic medication that was developed more than 50 years ago for use primarily by anesthesiologists for sedation during surgery. Ketamine is on the World Health Organization’s List of Essential Medicines, and is one of the most commonly used pharmaceuticals in the world.

In addition to being a powerful analgesic, ketamine is also known to have potent antidepressant and anti-inflammatory properties. As pain practitioners, we understand that pain and depression often times go hand-in-hand. In certain instances, the effect of chronic pain serves to amplify the symptoms of depression. Increased depression can amplify the feeling and symptoms of chronic pain.  Research suggests that ketamine has shown to be extremely valuable for its rapid and profound effectiveness in the treatment of depression, and other mood disorders, as well as neuropathic chronic pain conditions that have otherwise failed traditional treatments.

"Seeing her I can walk my dog and do daily activities and not in pain. I know she is different (in a good way) because I want to pain management up north and all they wanted to do is give me narcotics. I trust Dr. Sikora and would recommend her to my family and friends. I trust her with my life. Dr. Sikora is one of the very few Dr.s that are as empathetic and willing to listen that I’ve ever gone to or worked with. The staff are intelligent and very kind."

Is it covered by insurance?

We do not accept insurance for this treatment but patients can contact their individual insurance plan to check if they have any benefits.

Regenerative Medicine

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How does ketamine infusion therapy work?

Pain signals travel to and from our brain on an interconnected network of nerves which run throughout our body. Tiny receptors on these nerves called NMDA receptors collect information from the body and immediately alert the brain if damage or injury has occurred.

Many chronic pain syndromes are caused by a spike of these NMDA receptors in the brain. Studies have shown that spikes in these NMDA receptors in the brain play a significant role in major depression, chronic pain syndromes, fibromyalgia and other neurological disorders.

In cases of acute pain, the NMDA receptors subside following the usual course of injury and the pain signal eventually is turned off. With chronic pain, the NMDA receptors do not turn off and begin to multiply creating an amplified pain signal.

Ketamine, has the unique ability to interfere with those NMDA receptors and essentially block the pain signal from reaching the brain. When administered in a precise low dose IV infusion, ketamine provides virtually instantaneous relief of pain symptoms and allows nerve receptors the chance to reset or reboot themselves.

The ketamine infusion process at Sikora Integrative Medicine

Please schedule a consult to determine if you are a candidate. During this appointment, Dr. Sikora will perform a physical examination and a comprehensive review of your medical records with you to determine your appropriateness for ketamine treatment. If it is determined you are a candidate for ketamine infusion, Dr. Sikora will utilize the information from your examination to determine the proper ketamine dose, infusion rate and duration of the infusion.

Ketamine therapy will be administered on site at Sikora Integrative Medicine under close supervision of our trained medical personnel. Your infusion treatment will take place in a relaxed, comfortable environment. A trained member of our medical staff will start your IV and connect the necessary monitoring equipment that will be measuring your breathing, blood pressure, heart function, and other vital signs throughout the duration of your ketamine treatment.

To begin your treatment, a small dose of ketamine will intravenously be administered into your bloodstream. Once the treatment begins, it will typically take a few minutes before you begin to feel the actual effects of the medication. In many cases, relief can be experienced in as little as 15 minutes, although the appropriate frequency and longevity of treatment will depend on each patient’s specific condition and overall health. A typical ketamine infusion treatment lasts between 2-3 hours.

Once your ketamine infusion is complete, you will be monitored for 30 minutes prior to being discharged from your appointment. You will need a driver to take you home.

Who will likely benefit from ketamine infusion therapy?

    • Individuals with neuropathic pain that is not well controlled with injections, nerve blocks, or prescription pain medication.
    • Individuals with chronic back and neck pain no longer responsive to any form of treatment.
    • Individuals suffering from depression, PTSD and other mood disorders
    • Individuals with other debilitating musculoskeletal and joint pain.

What does ketamine infusion therapy treat?

    • We currently offer ketamine infusion therapy for all forms of neuropathic chronic pain including but not limited to:

      • Complex Regional Pain Syndrome (CRPS/RSD)
      • Fibromyalgia
      • Trigeminal Neuralgia
      • Headaches
      • Low back and neck pain

      We also offer ketamine infusion therapy for depression, anxiety, PTSD and other mood disorders. Patients must have an established and confirmed diagnoses prior to seeking ketamine treatment at Sikora Integrative Medicine..

Clinically Proven to Treat Pain & Migraines

-Chronic Pain

About 100 million Americans suffer from chronic pain. Chronic pain is defined as pain that lasts longer than six months, can be moderate or excruciating, episodic or continuous, inconvenient or totally incapacitating. With chronic pain, signals of pain inappropriately remain active in the nervous system for months or even years. The emotional toll of chronic pain also can make pain worse. Anxiety, stress, depression, anger, and fatigue interact in complex ways with chronic pain and may decrease the body’s production of natural painkillers. ​


Fibromyalgia is a chronic pain condition that affects the muscles and tissues of the body, causing symptoms of aching and stiffness. Pain can range from moderate to severe, and can affect various parts of the body at various times. This pain can be debilitating and still is not completely understood by the medical community.

We can successfully reduce patient’s chronic pain symptoms with low dose Ketamine infusions, allowing the patient to obtain relief from their symptoms. The effects can be dramatic, often allowing patients for the first time in years to re-engage in life activities they have missed out on for so long.

-Clinically Proven Depression Treatment

The symptoms of depression can place a massive burden on a patient and their family. We are here you offer you hope for a major reduction in your depression symptoms. ​ In the last 7-10 years, dozens of research studies have been published that show very promising results for the effectiveness of Ketamine infusions for treatment resistant depression (TRD). Even in these most difficult-to-treat cases, Ketamine can be successful up to 80% of the time. Ketamine is currently the only fast acting treatment proven to reduce the symptoms of even the most severe forms of depression.
Research has shown that a series of 6 low-dose Ketamine infusions, each lasting approximately 40 minutes, may rapidly reduce depressive symptoms and produces results that last as long as two-three months. Patients often report improved symptoms in as few as 1-2 treatments. This innovative therapy has even shown to produce results in patients that have been unresponsive to traditional depression therapy. ​ Ketamine infusions should be a part of a comprehensive treatment plan. We recommend that our infusions are part of a multidisciplinary plan that includes a mental health provider, a healthy diet, psychotherapy and plenty of physical activity. ​ For all patients, your overall mental health care must be directed by a primary care or mental health provider. We require that all patients have a history and physical exam prior to your first Ketamine Infusion.

-Complex Regional Pain Syndrome

Complex Regional Pain Syndrome (CRPS), also referred to Reflex Sympathetic Dystrophy (RSD), is a chronic neurological syndrome characterized by:

  • severe burning pain
  • pathological changes in bone and skin
  • excessive sweating
  • tissue swelling
  • extreme sensitivity to touch

Once diagnosed, traditional treatment options have been limited and offer little to no relief.

Physicians and researchers have identified that Ketamine infusions can provide patients immediate and sustained relief for these chronic pain conditions. Typically, between 1-3  four-hour Ketamine Infusions can result in patients obtaining up to three months of remission. Often patients report near 100% pain relief within hours of the start of the infusion. For best result physical therapy recommended in conjunction with the Ketamine Infusions. CRPS patients can also expect to significantly reduce their need to take opioids and other pain medications.


Migraines can be debilitating. We offer multiple fast acting acute migraine treatment options. These treatments include IV Ketamine infusions and IV micro-nutrient therapy (Magnesium and B-vitamin infusions).

"Excellent Doctor!! Considerate, kind, understanding and listens. Thankfully, Dr. Sikora has helped minimize my chronic fibromyalgia and back pain. Thanks to her, I feel so much better dealing with that crazy chronic pain!!! I’m fortunate to have found a healing and caring doctor right here in Vero… I highly recommend Dr. Sikora"